A registry study on brain metastases and disease progression in breast cancer to improve the long-term treatment of brain metastases

Breast cancer (mammary carcinoma) is a malignant disease of the breast tissue characterized by the uncontrolled proliferation of breast cells. If the breast cancer is very large or has spread to other parts of the body (metastases), the disease is considered to be at an advanced stage. Metastases can, in principle, occur anywhere, including in the brain. The incidence of brain metastases in patients with breast cancer has increased in recent years, resulting in a reduced quality of life and a poorer prognosis. However, knowledge about potential risk factors and appropriate treatments for brain metastases remains very limited.

The aim of this registry study is to collect data on the characteristics of breast cancer in connection with brain metastases and the subsequent course of treatment. This study aims to identify risk groups for the development of brain metastases in breast cancer. In the long term, based on the results of this registry, a study design for the early detection of brain metastases will be developed. The study is purely observational; no new drugs or forms of therapy are being investigated within the framework of the registry. Radiological imaging data and existing tissue samples from the tumors and metastases are being collected, and blood and cerebrospinal fluid samples are being analyzed.

Women and men aged 18 and older who have been diagnosed with breast cancer and brain metastases (diagnosed on or after the year 2000) are eligible to participate in this study.